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Can thyroid hormone mimics affect thyroid hormone measurement by immunoassay?

Authors
Journal
Clinical Biochemistry
0009-9120
Publisher
Elsevier
Volume
46
Identifiers
DOI: 10.1016/j.clinbiochem.2013.06.030
Keywords
  • Thyroid Hormones
  • Hormone Mimics
  • Immunoassay
  • Tetrabromobisphenol A (Tbbpa)
  • T4
Disciplines
  • Ecology
  • Geography

Abstract

Abstract Objectives This study aims to determine whether the environmental pollutant and thyroid mimic, tetrabromobisphenol A (TBBPA), interferes with thyroid hormone measurement by immunoassays. Design & methods Hormone-relevant concentrations of TBBPA were added to thyroid hormone-stripped human serum and subjected to 6 different thyroid hormone immunoassays. Results TBBPA was negative in all of the thyroid hormone immunoassays tested except at very high concentration (above that expected in serum of TBBPA-exposed workers) where it gave a marginally positive result in one immunoassay (in house T4 radioimmunoassay (RIA)). Conclusions Serum TBBPA present as a result of workplace exposure or its use as a fabric flame retardant is very unlikely to give false positive results in thyroid hormone immunoassays.

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