Affordable Access

Publisher Website

Can thyroid hormone mimics affect thyroid hormone measurement by immunoassay?

Authors
Journal
Clinical Biochemistry
0009-9120
Publisher
Elsevier
Volume
46
Identifiers
DOI: 10.1016/j.clinbiochem.2013.06.030
Keywords
  • Thyroid Hormones
  • Hormone Mimics
  • Immunoassay
  • Tetrabromobisphenol A (Tbbpa)
  • T4
Disciplines
  • Ecology
  • Geography

Abstract

Abstract Objectives This study aims to determine whether the environmental pollutant and thyroid mimic, tetrabromobisphenol A (TBBPA), interferes with thyroid hormone measurement by immunoassays. Design & methods Hormone-relevant concentrations of TBBPA were added to thyroid hormone-stripped human serum and subjected to 6 different thyroid hormone immunoassays. Results TBBPA was negative in all of the thyroid hormone immunoassays tested except at very high concentration (above that expected in serum of TBBPA-exposed workers) where it gave a marginally positive result in one immunoassay (in house T4 radioimmunoassay (RIA)). Conclusions Serum TBBPA present as a result of workplace exposure or its use as a fabric flame retardant is very unlikely to give false positive results in thyroid hormone immunoassays.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments