In recent years scientists" attention has been attracted by interhemispheric relations of people addicted to psychoactive drugs. Some writings contain information about disorders in motor and sensory lateralisation among patients with opium addiction and alcoholism. The peculiarities of lateralisation of motor, sensory and cognitive characteristics among people with drug addiction, alcoholism and toxicomania were studied in comparison with a relevant reference group. The battery of tests, helping to identify lateralisation of motor (response hand, leg), sensory (eye, ear) and cognitive (dextro- or sinistrocerebral mode in performing of verbal and/or spatial tasks), was used for revelation of interhemispheric asymmetry profiles. Patients with drug addiction, alcoholism and toxicomania show sufficient domination of left-side lateralisation of motor and sensory characteristics in comparison with the reference group. The dextrocerebral mode dominated substantially in solving of verbal and spatial tasks.