Affordable Access

Publisher Website

Platelet function in familial hypercholesterolaemia in south africa and the effects of probucol

Authors
Journal
Thrombosis Research
0049-3848
Publisher
Elsevier
Publication Date
Volume
26
Issue
2
Identifiers
DOI: 10.1016/0049-3848(82)90018-4
Keywords
  • Familial Hypercholesterolaemia
  • Platelet Function
  • Probucol Therapy
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Patients with Familial Hyperlipoproteinaemia Type II showed evidence of increased platelet aggregability when compared to normal controls. This abnormality was not influenced by oral therapy with probucol whether or not the serum cholesterol levels were lowered during the study period. Probucol assays indicated adequate compliance during the study period but did not demonstrate any uptake of the drug by platelets. In vitro studies also failed to demonstrate any inhibition of platelet function at therapeutic drug levels although higher levels were inhibitory.

There are no comments yet on this publication. Be the first to share your thoughts.