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Computer-assisted estimates of lesion sizes and shrinkage in denervated areas from receptor autoradiograms using a digitizing tablet

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
44
Issue
3
Identifiers
DOI: 10.1016/0304-3940(84)90035-1
Keywords
  • Lesion
  • Receptors
  • Supersensitivity
  • Shrinkage
  • Striatum
  • Pallidum
  • Substantia Nigra
  • Autoradiography

Abstract

Abstract Area measurements taken from receptor autoradiograms were employed to estimate the size of striatal kainate lesions and the amount of shrinkage in deafferented projection areas. There was no significant difference in the size of substantia nigra (SN) on the denervated side as compared to the intact side one week and one month after unilateral striatal lesions. Although there was no change in the size of globus pallidus (GP) on the lesioned side one week after the lesion, there was a 17% shrinkage one month after the lesion. At 3–4 months after the lesion, the amount of shrinkage was 19% in SN and 16% in GP.

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