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Intracranial metastases in patients with squamous cell carcinoma of the head and neck

Authors
Journal
Otolaryngology - Head and Neck Surgery
0194-5998
Publisher
SAGE Publications
Publication Date
Volume
124
Issue
2
Identifiers
DOI: 10.1067/mhn.2001.112478
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Background: Intracranial metastases are rarely clinically diagnosed in patients with head and neck squamous cell carcinoma. Only 7 patients with metastases to the cavernous sinus from head and neck squamous cell carcinomas have been reported. Methods: A retrospective study revealed 13 patients with intracranial metastases of head and neck squamous cell carcinoma. In a 53-year-old woman a cavernous sinus metastasis of a laryngeal carcinoma was histologically diagnosed by using a CT-guided surgical navigation system and was treated with stereotactic radiotherapy. Results: The mean survival was 4.3 months. Predictive factors for longer survival were absence of extracranial disease, age younger than 60 years, and treatment with radiotherapy. Conclusions: The prognosis for patients with intracranial disease is poor. The current development of computer-assisted stereotactic navigation and stereotactic radiotherapy may facilitate surgical diagnostic exploration and improve treatment, especially in patients without extracranial disease.

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