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Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates

Authors
Journal
Mutation Research Letters
0165-7992
Publisher
Elsevier
Publication Date
Volume
103
Issue
1
Identifiers
DOI: 10.1016/0165-7992(82)90090-2

Abstract

Abstract 3-Chloro-1,2-propanediol and 1,3-dichloro-2-propanol caused base substitutions in Salmonella typhimurium TA1535 both with and without metabolic activation. Metabolic activation seemed to act mainly by decreasing the toxicity of these compounds. A difference in the growth of the wild-type and repair-deficient strains of Escherichia coli was observed only for 1,3-dichloro-2-propanol with S9 mix. Esters of both chlorohydrines with fatty acids had smaller mutagenic effects than unesterified compounds.

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