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Use of Vitamin C as Placebo in Anesthesiology

Anesthesiology and Pain Medicine
Kowsar Medical Institute
Publication Date
DOI: 10.5812/aapm.8055
  • Letter
  • Medicine


KOWSAR Anesthesiology Pain Medicine Anesth Pain. 2013;2(3):141. DOI: 10.5812/aapm.8055 Use of Vitamin C as Placebo in Anesthesiology Masood Mohseni 1* 1 Department of Anesthesiology, Rasoul Akram Medical Center, Iran University of Medical Sciences (IUMS), Tehran, Iran A R T I C L E I N F O Article history: Received: 03 Sep 2012 Revised: 18 Sep 2012 Accepted: 01 Oct 2012 Keywords: Placebos Clinical Trial Anesthesia Pain Article type: Letter Please cite this paper as: Mohseni M. Use of Vitamin C as Placebo in Anesthesiology. Anes- th Pain. 2013;2(3):141. DOI: 10.5812/aapm.8055 Dear Editor, I was interested to read the paper entitled “Effects of clonidine premedication upon postoperative shivering and recovery time in opium addicted and non-addicted patients by elective leg fracture surgeries” (1). I note that the authors administered vitamin C tablet as placebo for clonidine. Noteworthy, earlier animal studies have sug- gested that there is a close relationship between recovery from anesthesia and extracellular ascorbic acid levels (2). Vitamin C has showed pain relieving effects (3) namely in complex regional pain syndrome (4), post herpetic neu- ralgia (5), migraine headache (6) and myalgia associated with the administration of suxamethonium (7). More- over, the placebo tablet should be identical-looking with similar color, taste, and smell with the treatment drug. I guess that vitamin C with its particular taste and smell could be easily distinguished from clonidine. Taken to- gether, I believe that since vitamin C has the potential to affect outcome in this study, it may not be an appropriate choice for placebo. Financial Disclosure None declared. References 1. Mirkheshti A. Effects of Clonidine Premedication Upon Postoper- ative Shivering and Recovery Time in Patients With and Without Opium Addiction After Elective Leg Fracture Surgeries. Anesth Pain. 2013;2(3):107-110. 2. Crespi F, Mobius C, Keane P. E

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