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Letter re: "Cyclosiloxanes produce fatal liver and lung damage in mice".

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Journal
Environmental Health Perspectives
0091-6765
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Environmental Health Perspectives
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  • Letter

Abstract

Correspondence with 'H nuclear magnetic resonance (NMR) technique using an internal con- trol (5). Blood samples from animals given feed without siloxanes showed no signals originating from the silicones tested. In all blood samples from animals given feed with siloxanes, they were detected. In sam- ples from animals given feed with PDMS, the mean concentration (± standard devia- tion) of siloxanes of 26 ± 14 pg/cm3 was noted; in samples from animals given feed with cPDMS, the mean concentration of siloxanes of 70 ± 97 pg/cm3 was noted. The difference was not significant. These results conform well to those obtained pre- viously in Rhesus monkeys by Calandra et al. (6). In our opinion, the absorption and toxicity of siloxane-based drugs should be more intensively studied. Our study was supported by the Polish State Committee for Scientific Research (KBN) (grant 4P05D06612). Jerzy Lukasiak Zygmunt Jamr6giewicz Bogdan Falkiewicz Medical University of Gdansk and University of Gdansk Gdansk, Poland E-mail: [email protected] REFERENCES AND NOTES 1. Lieberman MW, Lykissa ED, Barrios R, Ou CN, Kala G, Kala SV. Cyclosiloxanes produce fatal liver and lung damage in mice. Environ Health Perspect 107:161-165 (1999). 2. Great Britain Medicines Commission. British Pharmacopeia 1993. London:Her Majesty's Stationery Office, 1993. 3. The United States Pharmacopeia, 22nd revision. Rockville, MD:U.S. Pharmacopeial Convention, 1990. 4. Lukasiak J, Jamr6giewicz Z, Czarnowski W, Krechniak J, Falkiewicz B. Assessment of polydi- methylsiloxanes and cyclopolydimethylsiloxanes: intestinal absorption in rats with analysis of their blood concentrations using 1H NMR [in Polish]. Bromatol Chem Toksykol 32:99-101 (1999). 5. Jamr6giewicz Z, Lukasiak J, Mojsiewicz K. Application of the NMR spectrometry to speciation analysis of polydimethylsiloxane. Chem Anal (Warsaw) 42:659-666 (1997). 6. Calandra JC, Keplinger ML, Hobbs EJ, Tyler LJ. Health and enviromental aspects of polydimethyl- siloxane

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