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Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fosexpression in the suprachiasmatic nucleus of mice

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
966
Issue
1
Identifiers
DOI: 10.1016/s0006-8993(02)04195-1
Keywords
  • Calcium
  • Calcium Antagonist
  • Phase Delay
  • Immediate Early Gene

Abstract

Abstract The present study assessed whether treatment with the L-type calcium channel antagonist nimodipine affects the responsiveness of the circadian pacemaker to light in C3H/HeN mice. Nimodipine (10 mg/kg, sc) increased the magnitude of light-induced phase delays ( P<0.01) and c- fos mRNA expression in the paraventricular nuclei ( P<0.01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c- fos expression in the SCN.

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