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Na+channels as targets for neuroprotective drugs

Authors
Journal
Trends in Pharmacological Sciences
0165-6147
Publisher
Elsevier
Publication Date
Volume
16
Issue
9
Identifiers
DOI: 10.1016/s0165-6147(00)89060-4
Disciplines
  • Design
  • Medicine
  • Philosophy

Abstract

Abstract Drugs that block voltage-dependent Na + channels are well known as local anaesthetics, antiarrhythmics and anticonvulsants. Recent studies show that these compounds also provide a powerful mechanism of cytoprotection in animal models of cerebral ischaemia, hypoxia or head trauma. In this article Charles Taylor and Brian Meldrum review evidence indicating that Na + channel modulators are neuroprotective and describe recent ideas for the molecular sites of action of voltage-dependent Na + channel blockers. Clinical trials with several compounds are now in progress for stroke and traumatic head injury, and the therapeutic potential for this group of compounds is discussed.

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