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The ‘presynaptic’ blocking potency of sulpiride and haloperidol in the rat is age-dependent

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
46
Issue
2
Identifiers
DOI: 10.1016/0304-3940(84)90442-7
Keywords
  • Pergolide
  • Sulpiride
  • Haloperidol
  • Locomotor Inhibition
  • Blockade
  • Presynaptic Receptor
  • Behavioural Model
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract A low dose of pergolide (0.01 mg/kg) caused a marked inhibition of locomotor activity in male rats. Sulpiride significantly blocked the locomotor inhibition in young (6 weeks of age) rats already in low (2.5 μmol/kg) doses, while in adult (15 weeks of age) rats a blockade was achieved first with high ‘postsynaptic’ doses (50 μmol/kg). Haloperidol slightly blocked the effect of pergolide in both young and adult rats. However, the blocking action of haloperidol was only found in a narrow pharmacological ‘window’ (0.05 μmol/kg). This study illustrates the importance of considering age-related variations when using behavioural models of ‘presynaptic’ dopaminergic agonistic activity. It is suggested that ‘presynaptic’ dopaminergic events are modulated by hormonal changes during growth.

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