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The reovirus nonstructural protein sigma1NS is recognized by murine cytotoxic T lymphocytes.

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Publication Date
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PMC
Keywords
  • Research Article
Disciplines
  • Biology

Abstract

The cytotoxic T-lymphocyte (CTL) response in reovirus-infected C3H mice was investigated by using reovirus-vaccinia virus recombinants. Results of cytotoxicity assays indicated that the nonstructural protein sigma1NS elicited a significant CTL response. Experiments with sigma1NS-specific CTL lines showed that both strain-specific and cross-reactive epitopes exist in the sigma1NS protein.

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