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Malignant hyperthermia in pigs: A search for abnormalities in Ca2+binding proteins

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
153
Issue
1
Identifiers
DOI: 10.1016/0014-5793(83)80123-9
Keywords
  • Muscular Hyperthermia
  • Pig Troponin C
  • Tryptic Peptide Mapping
  • Calmodulin
Disciplines
  • Biology

Abstract

Abstract Malignant hyperthermia occurs in man and pigs as a hereditary disorder notably as a complication of halotane-induced anaesthesia. It involves an abnormality in the metabolism of Ca 2+. A search was made for abnormalities of calcium-binding proteins. Troponin C from normal pig muscle was found to differ in 2 of 159 amino acids from rabbit Tn C and 3 from man. No differences between normal and abnormal pig muscle were found. Two-dimensional electrophoresis of red cell calmodulin from normal and abnormal pigs also failed to demonstrate a difference.

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