Affordable Access

Publisher Website

6,7,4′-trihydroxyisoflavan: A potent and selective inhibitor of 5-lipoxygenase in human and porcine peripheral blood leukocytes

Authors
Journal
Prostaglandins & Other Lipid Mediators
0090-6980
Publisher
Elsevier
Publication Date
Volume
28
Issue
6
Identifiers
DOI: 10.1016/0090-6980(84)90035-2

Abstract

Abstract The effect of 6,74′-trihydroxyisoflavan on human platelet 12-lipoxygenase and human and porcine PMNL 5-lipoxygenase activities has been studied. 6,7,4′-Trihydroxyisoflavan was found to inhibit 5-lipoxygenase more strongly than 12-lipoxygenase; its concentration for 50% inhibition (IC 50) was 1.6 μm for human and porcine 5-lipoxygenase adn 22 μM for human platelet 12-lipoxygenase. Inhibition of microsomal cyclooxygenase from ram seminal vesicles is exhibited at much higher concentrations of 6,7,4′-trihydroxyisoflavan (IC 50 = 200 μM).

There are no comments yet on this publication. Be the first to share your thoughts.