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High melting lipid based approach for drug delivery: Solid lipid nanoparticles

Authors
Journal
Materials Science and Engineering C
0928-4931
Publisher
Elsevier
Publication Date
Volume
33
Issue
4
Identifiers
DOI: 10.1016/j.msec.2013.01.037
Keywords
  • Solid Lipid Nanoparticles
  • Drug Delivery System
  • Surfactants
Disciplines
  • Biology
  • Pharmacology

Abstract

Abstract Poor solubility of newly developed drug molecules is the main problem in recent drug discovery research, so novel drug delivery approaches are being used to deliver these molecular entities for pharmacological action. Colloidal carriers (emulsion, suspensions, liposomes, polymer nanoparticles and solid lipid nanoparticles) have been used to administer poorly soluble drugs, but solid lipid nanoparticles are found to be the most reliable carriers for this type of drugs due to its advantages over other carriers. Solid lipid nanoparticles have the potential to solve the drug delivery problems with safe excipients used in its formulation. In this review all the aspects of solid lipid nanoparticles production, stability, characterization, differentiation based on route, preservation and storage have been discussed.

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