Affordable Access

Virilization persists in a woman with an androgen-secreting granulosa cell tumor

Authors
Journal
Fertility and Sterility
0015-0282
Publisher
Elsevier
Publication Date
Volume
91
Issue
3
Identifiers
DOI: 10.1016/j.fertnstert.2008.10.038
Keywords
  • Granulosa Cell Tumor
  • Virilizing
  • Masculinizing
  • Androgen
  • Testosterone
  • Inhibin
Disciplines
  • Biology
  • Medicine

Abstract

Objective To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization. Design Case report. Setting University medical center. Patient(s) A 45-year-old woman with abrupt onset of virilization with high serum androgen levels. Intervention(s) Exploratory laparotomy with full staging. Main Outcome Measure(s) Surgical findings and histopathologic observations are included in this report. Result(s) Pathologic examination revealed an inhibin stain positive GC tumor of the adult type. Virilization has persisted for 8 years after surgery. Conclusion(s) Adult-type GC tumor is an extremely rare cause of virilization. Masculinization features may persist in the absence of high androgen levels.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Endocrine studies in a case of profound virilizati...

on Zentralblatt für Gynäkologie 1993

Virilization syndrome in a young woman due to an a...

on Journal of endocrinological in... February 1984

Virilization due to a metastasizing granulosa cell...

on International journal of gynec... 1983
More articles like this..