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ORAL IMMUNISATION WITH KILLED HAEMOPHILUS INFLUENZAE FOR PROTECTION AGAINST ACUTE BRONCHITIS IN CHRONIC OBSTRUCTIVE LUNG DISEASE

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
326
Identifiers
DOI: 10.1016/s0140-6736(85)92559-0
Disciplines
  • Medicine

Abstract

Abstract Fifty patients with chronic obstructive lung disease were randomly allocated to three groups, to assess whether an oral vaccine containing non-typable Haemophilus influenzae protected against acute bronchitis. The double-blind prospective study over a three month winter period included two placebo groups and one test group. Oral immunisation with H influenzae induced a tenfold reduction in the incidence of infection (p<0·001). During the subsequent winter, without further immunisation, protection by the vaccine was no longer statistically significant. There was no clear correlation between clinical protection and either carriage of H influenzaeor the level of antibody to H influenzae antigen in saliva.

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