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Hypoxia: The driving force of uterine myometrial stem cells differentiation into leiomyoma cells

Authors
Journal
Medical Hypotheses
0306-9877
Publisher
Elsevier
Volume
77
Issue
6
Identifiers
DOI: 10.1016/j.mehy.2011.08.026
Disciplines
  • Biology

Abstract

Abstract We propose that stem cells that display specific phenotypic and functional characteristics exist in human uterine myometrium. Under hypoxic circumstances, estrogen signaling pathways in certain myometrial stem cells are aberrantly activated, which leads to continuous differentiation of this portion of cells into leiomyoma cells. This process also protects the cells from undergoing physiological apoptotic or dedifferentiation. Therefore, we summarized some evidences for our bases and hypothesize that hypoxia may be the key contributor to the pathogenesis of leiomyoma through aberrant estrogen pathway activation of myometrial stem cells.

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