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ABC: software for interactive browsing of genomic multiple sequence alignment data

BioMed Central
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  • Software
  • Biology
  • Computer Science

Abstract ral ss BioMed CentBMC Bioinformatics Open AcceSoftware ABC: software for interactive browsing of genomic multiple sequence alignment data Gregory M Cooper1, Senthil AG Singaravelu1 and Arend Sidow*1,2 Address: 1Department of Genetics, Stanford University, Stanford, CA 94305-9010, USA and 2Department of Pathology, Stanford University, Stanford, CA 94305-5324, USA Email: Gregory M Cooper - [email protected]; Senthil AG Singaravelu - [email protected]; Arend Sidow* - [email protected] * Corresponding author Abstract Background: Alignment and comparison of related genome sequences is a powerful method to identify regions likely to contain functional elements. Such analyses are data intensive, requiring the inclusion of genomic multiple sequence alignments, sequence annotations, and scores describing regional attributes of columns in the alignment. Visualization and browsing of results can be difficult, and there are currently limited software options for performing this task. Results: The Application for Browsing Constraints (ABC) is interactive Java software for intuitive and efficient exploration of multiple sequence alignments and data typically associated with alignments. It is used to move quickly from a summary view of the entire alignment via arbitrary levels of resolution to individual alignment columns. It allows for the simultaneous display of quantitative data, (e.g., sequence similarity or evolutionary rates) and annotation data (e.g. the locations of genes, repeats, and constrained elements). It can be used to facilitate basic comparative sequence tasks, such as export of data in plain-text formats, visualization of phylogenetic trees, and generation of alignment summary graphics. Conclusions: The ABC is a lightweight, stand-alone, and flexible graphical user interface for browsing genomic multiple sequence alignments of specific loci, up to hundreds of kilobases or a few megabases in length. It is coded in Java for cross-platform

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