Affordable Access

Publisher Website

The effect of specific hormones on fibrinolysis in pregnancy

Authors
Journal
American Journal of Obstetrics and Gynecology
0002-9378
Publisher
Elsevier
Publication Date
Volume
175
Issue
1
Identifiers
DOI: 10.1016/s0002-9378(96)70269-7
Keywords
  • Tissue-Type Plasminogen Activator
  • Plasminogen Activator Inhibitor-1
  • Endothelium
  • Pregnancy
  • Estradiol-17β
  • Progesterone
  • Prolactin
  • Hydrocortisone
Disciplines
  • Biology

Abstract

Abstract OBJECTIVE: Plasminogen activator inhibitor-1, the major serum protease inhibitor of fibrinolysis, increases steadily during pregnancy. The study objective was to examine four hormones, namely, estradiol-17β, progesterone, prolactin, and hydrocortisone to determine their individual contributions in the production of tissue plasminogen activator antigen, plasminogen activator inhibitor-1 antigen, and plasminogen activator inhibitor-1 activity. STUDY DESIGN: Human umbilical vein endothelial cells were grown with physiologic third-trimester concentrations of the above hormones, and fibrinolytic parameters were measured. RESULTS: Of the four hormones evaluated, only hydrocortisone significantly increased plasminogen activator inhibitor-1 antigen and activity at both concentrations tested ( p < 0.001). Estradiol-17 β significantly increased tissue plasminogen activator antigen and progesterone significantly decreased tissue plasminogen activator antigen, but neither affected the overall fibrinolytic balance. CONCLUSION: Hydrocortisone demonstrated antifibrinolytic properties at physiologic concentrations in pregnancy, suggesting that there may be a role for hydrocortisone in the prothrombotic tendency associated with pregnancy. The overall process of fibrinolysis was unaffected by estradiol-17β, progesterone, or prolactin. (Am J Obstet Gynecol 1996;175:168-72.)

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The effect of specific hormones on fibrinolysis in...

on American Journal of Obstetrics... July 1996

[Effect of pregnancy interruption on the euglobuli...

on Wiadomości lekarskie (Warsaw,... Sep 01, 1968

Effects of pregnancy and sex hormones on the liver...

on Seminars in liver disease February 1987

The effects of sex hormones on the immune system i...

on American journal of reproducti... 1992
More articles like this..