Abstract In recent years great interest and clinical activity have been directed toward the grafting of soft tissues within the oral cavity. Procedures have been devised for utilizing autogenous skin and palatal and buccal mucosa. Porcine (pigskin) xenografts have become commercially available for use as a biologic dressing for intermediate coverage of defects. Research on burns, decubitus ulcers, thermal tissue loss, and traumatic skin loss has demonstrated favorable clinical results. This preliminary report on the clinical use of pigskin in 25 unselected cases involving oral plastic, reconstructive, and ablative procedures illustrates its potential for further study as well as its effectiveness and convenience.