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Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
13
Issue
24
Identifiers
DOI: 10.1016/j.bmcl.2003.09.013

Abstract

Abstract Ureas of 5-aminopyrazole and 2-aminothiazole emerged as lead compounds from a high-throughput screen assaying the growth of Staphylococcus aureus. Structure–activity relationships were developed for each compound series. Several compounds were also tested for activity against drug resistant strains of S. aureus in vivo.

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