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Differential effects of hydralazine on the biphasic responses of helical strips from rat tail arteries

Authors
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
14
Issue
1
Identifiers
DOI: 10.1016/0306-3623(83)90079-4

Abstract

Abstract 1. 1. In helical strips prepared from rat tail arteries, hydralazine preferentially depressed the slow phase of noradrenaline-induced contractions and the rapid phase of KCl-induced contractions. 2. 2. Its effect was lost in a calcium free medium and in strips depolarized with KCl and subsequently contracted with noradrenaline. 3. 3. The results suggest that hydralazine, at least at high concentrations, may interfere with the transmembrane movements of calcium ions in vascular smooth muscle.

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