Affordable Access

Publisher Website

Inhibitory ITAMs: a matter of life and death

Authors
Journal
Trends in Immunology
1471-4906
Publisher
Elsevier
Publication Date
Volume
29
Issue
8
Identifiers
DOI: 10.1016/j.it.2008.05.001
Disciplines
  • Medicine

Abstract

The balance between activating and inhibitory signals is essential to control immune responses to microorganisms. Innate and adaptive immune responses are regulated by receptors that signal through either an immunoreceptor tyrosine-based activation motif (ITAM) or an immunoreceptor tyrosine-based inhibitory motif (ITIM). When clustered, these motifs are, respectively, responsible for activating and inhibitory signals. Recently, the concept of inhibitory ITAM (ITAM i) has emerged as a new means to negatively control the immune response. In this Opinion, we will discuss the ability of Escherichia coli to evade the immune system by eliciting ITAM i function through FcγRIII (CD16) on phagocytes leading to uncontrolled systemic infection and sepsis. Elucidating such mechanisms will open opportunities for specific therapeutic manipulation of ITAM i-based signaling pathways.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

A matter of life and death.

on The New Scientist Jul 27, 1996

On matters of life and death.

on U.S. Catholic March 1982

A matter of life and death.

on Medical law review 1995
More articles like this..