Tithonia diversifolia (wild sunflower) leaves were harvested, sundried and milled to obtain Tithonia diversifolia leaf meal (TDLM). Samples of the TDLM were analysed for proximate composition, amino acid profile and certain antinutrients. Analysis revealed a composition of 20.6% CP, 18.9% CF, 4.0% EE, 42.5% CHO and 14.0% ash. Phytin was high at 79.10 mg/100 g. Saponin, oxalate and alkaloids were also present at 2.36, 1.76 and 1.23 mg/100 g, respectively. Tannin and flavonoid were in traces of 0.39 and 0.87mg/100g, respectively. The contents of lysine, arginine, aspartate, glutamate, methionine+cystine, isoleucine, tyrosine and phenylalanine were remarkably high at 5.3, 6.19, 13.32, 12.19, 2.60, 4.28, 7.55, 3.53 and 5.47g/100g protein. The ample presence of ANFs (phytins, oxalates, flavonoids and saponnins) portends a negativenutritional evaluation for TDLM as a potential non-ruminant feed ingredient. ANFs have been suggested as a probable militating factor hindering the digestibility of crude protein (CP) and amino acids (AAs) in most plant products. The ample presence of some essential amino acids particularly isoleucine, leucine and lysine and other aromatic amino acids like phenylalanine and valine were remarkable suggestion of the potentiality of TDLM as a veritable alternative protein resource in non-ruminant feeding.