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F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).

Authors
Type
Published Article
Journal
Journal of Biological Chemistry
1083-351X
Publisher
American Society for Biochemistry and Molecular Biology
Publication Date
Volume
289
Issue
31
Pages
21508–21518
Identifiers
DOI: 10.1074/jbc.M114.560342
PMID: 24936062
Source
Medline
Keywords
  • Apoptosis
  • Cancer
  • F-Box Protein
  • Fbxo31
  • Mkk6
  • Protein Degradation
  • Stress Response
  • Ubiquitination
  • P38 Mapk

Abstract

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