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Extrusion of niosomes from capillaries: approaches to a pulsed delivery device.

Authors
  • Arunothayanun, P1
  • Sooksawate, T
  • Florence, A T
  • 1 Centre for Drug Delivery Research, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Type
Published Article
Journal
Journal of Controlled Release
Publisher
Elsevier
Publication Date
Aug 05, 1999
Volume
60
Issue
2-3
Pages
391–397
Identifiers
PMID: 10425343
Source
Medline
License
Unknown

Abstract

We describe an early prototype of a pulsatile delivery system for drug containing vesicles. Nonionic surfactant vesicles (niosomes) of average diameter 4-30 microm are extruded from glass capillaries (exit diameter, 5-10 microm), using air pressures of 0.5-5 p.s.i. The formulation of the vesicles is vital. Extrusions were affected by the size, shape, and membrane composition of the niosomes used. Spherical or polyhedral niosomes, formed by polyoxyethylene alkyl ethers with and without cholesterol, respectively, with diameters larger than the exit diameter of the capillary do not retain their membrane integrity on extrusion and were sheared to form new ultrastructures. The expulsion of single or groups of intact polystyrene microspheres or tetradecyl-beta-D-maltoside niosomes with sizes smaller than the exit diameter can be achieved readily. The stepwise release profile of luteinizing hormone releasing hormone (LHRH) obtained after pulsatile expulsion of groups of niosomes entrapping LHRH indicates the feasibility of this system for pulsatile delivery of vesicles, although it requires miniaturization.

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