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Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features.

Authors
  • Ronchi, Andrea1
  • Cozzolino, Immacolata1
  • Montella, Marco1
  • Panarese, Iacopo1
  • Zito Marino, Federica1
  • Rossetti, Sabrina2
  • Chieffi, Paolo3
  • Accardo, Marina1
  • Facchini, Gaetano2
  • Franco, Renato1
  • 1 Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "L. Vanvitelli", Naples, Italy. , (Italy)
  • 2 Uro-Andrologic Oncology Unit, Department of Uro-Gynaecological Oncology, Istituto Nazionale Tumori "Fondazione G. Pascale"-IRCCS, Naples, Italy. , (Italy)
  • 3 Department of Psychology, University of Campania "L. Vanvitelli", Caserta, Italy. , (Italy)
Type
Published Article
Journal
Cancer Medicine
Publisher
Wiley
Publication Date
Nov 01, 2019
Volume
8
Issue
16
Pages
6832–6840
Identifiers
DOI: 10.1002/cam4.2195
PMID: 31568647
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

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