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Extraction of Flavonoids From Natural Sources Using Modern Techniques

  • Chaves, Jaísa Oliveira1
  • de Souza, Mariana Corrêa1
  • da Silva, Laise Capelasso1
  • Lachos-Perez, Daniel2
  • Torres-Mayanga, Paulo César3, 4
  • Machado, Ana Paula da Fonseca3
  • Forster-Carneiro, Tânia3
  • Vázquez-Espinosa, Mercedes5
  • González-de-Peredo, Ana Velasco5
  • Barbero, Gerardo Fernández5
  • Rostagno, Mauricio Ariel1
  • 1 Multidisciplinary Laboratory in Food and Health, School of Applied Sciences, University of Campinas, Limeira , (Brazil)
  • 2 Laboratory of Optimization, Design and Advanced Control - Bioenergy Research Program, School of Chemical Engineering, University of Campinas, Campinas , (Brazil)
  • 3 School of Food Engineering, University of Campinas, Campinas , (Brazil)
  • 4 Facultad de Ingeniería, Universidad Nacional Micaela Bastidas de Apurímac, Abancay , (Peru)
  • 5 Department of Analytical Chemistry, Faculty of Sciences, University of Cadiz, Cadiz , (Spain)
Published Article
Frontiers in Chemistry
Frontiers Media S.A.
Publication Date
Sep 25, 2020
DOI: 10.3389/fchem.2020.507887
PMID: 33102442
PMCID: PMC7546908
PubMed Central


Flavonoids are one of the main groups of polyphenols found in natural products. Traditional flavonoid extraction techniques are being replaced by advanced techniques to reduce energy and solvent consumption, increase efficiency and selectivity, to meet increased market demand and environmental regulations. Advanced technologies, such as microwaves, ultrasound, pressurized liquids, supercritical fluids, and electric fields, are alternatives currently being used. These modern techniques are generally faster, more environmentally friendly, and with higher automation levels compared to conventional extraction techniques. This review will discuss the different methods available for flavonoid extraction from natural sources and the main parameters involved (temperature, solvent, sample quantity, extraction time, among others). Recent trends and their industrial importance are also discussed in detail, providing insight into their potential. Thus, this paper seeks to review the innovations of compound extraction techniques, presenting in each of them their advantages and disadvantages, trying to offer a broader scope in the understanding of flavonoid extraction from different plant matrices.

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