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Extraction of daunorubicin and doxorubicin and their hydroxyl metabolites: self-association in aqueous solution.

Authors
Type
Published Article
Journal
Journal of pharmaceutical sciences
Publication Date
Volume
67
Issue
6
Pages
782–785
Identifiers
PMID: 660455
Source
Medline
License
Unknown

Abstract

The extraction of daunorubicin and doxorubicin and their hydroxyl metabolites daunorubicinol and doxorubicinol was studied using chloroform-1-pentanol (9:1) as the organic phase. Because of differences in acid dissociation constants, the pH for optimum extraction varied from 8.0 to 8.6 for the different compounds. Self-association in the aqueous phase significantly influenced the distribution ratio. Constants for the formation of dimers and tetramers in aqueous solutions were about 10(4.5) and 10(12), respectively.

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