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An extract of Pueraria tuberosa tubers attenuates diabetic nephropathy by upregulating matrix metalloproteinase-9 expression in the kidney of diabetic rats.

Authors
  • Tripathi, Yamini B1
  • Shukla, Rashmi1
  • Pandey, Nidhi1
  • Pandey, Vivek1
  • Kumar, Mohan2
  • 1 Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, Varanasi, 221005, India. , (India)
  • 2 Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India. , (India)
Type
Published Article
Journal
Journal of diabetes
Publication Date
February 2017
Volume
9
Issue
2
Pages
123–132
Identifiers
DOI: 10.1111/1753-0407.12393
PMID: 26924185
Source
Medline
Keywords
License
Unknown

Abstract

Treatment of DN rats with PTY-2 significantly attenuated the severity of DN by increasing the expression and activity of Mmp-9, consequently degrading the ECM accumulated in kidney tissue.

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