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Extracorporeal immunoadsorption with IM-PH or IM-TR column.

Authors
  • Yamazaki, Z
  • Idezuki, Y
  • Inoue, N
  • Yoshizawa, H
  • Yamawaki, N
  • Inagaki, K
  • Tsuda, N
Type
Published Article
Journal
Biomaterials, artificial cells, and artificial organs
Publication Date
Jan 01, 1989
Volume
17
Issue
2
Pages
117–124
Identifiers
PMID: 2673426
Source
Medline
License
Unknown

Abstract

In order to selectively remove pathogenic macromolecular reactants, a biological affinity type adsorbent (a DNA colloidin charcoal column or protein A sepharose CL4B = Prosorba) has been developed and used for the treatment of immune disorders, alloimmunization and cancer. However, because physiologically active materials are required in this procedure, it is difficult to ensure an adequate supply of raw materials (and their handling, sterilization and preservation as an immunoadsorbent. To overcome the above-mentioned problems, we developed physicochemical type immunoadsorbents IM-TR and IM-PH, which consist of polyvinyl alcohol gel where tryptophan, in the former, and phenylalanine, in the latter, is used as a ligand. IM-PH has a better selectivity than IM-TR, however, IM-TR is a more efficient adsorbent of anti-acethylcholine receptor antibody than IM-PH. IM-PH plasma perfusion has been successfully used with patients with rheumatoid arthritis, systemic lupus erythematosus (SLE), and multiple sclerosis (MS).

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