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Antioxidant Therapies for Neuroprotection-A Review.

Authors
  • Teleanu, Raluca Ioana1
  • Chircov, Cristina2
  • Grumezescu, Alexandru Mihai3
  • Volceanov, Adrian4
  • Teleanu, Daniel Mihai5
  • 1 "Victor Gomoiu" Clinical Children's Hospital, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. [email protected]. , (Oman)
  • 2 Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania. [email protected]. , (Oman)
  • 3 Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania. [email protected]. , (Oman)
  • 4 Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania. [email protected]. , (Oman)
  • 5 Emergency University Hospital, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. [email protected]. , (Oman)
Type
Published Article
Journal
Journal of Clinical Medicine
Publisher
MDPI AG
Publication Date
Oct 11, 2019
Volume
8
Issue
10
Identifiers
DOI: 10.3390/jcm8101659
PMID: 31614572
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Although moderate concentrations of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are crucial for various physiological processes within the human body, their overproduction leads to oxidative stress, defined as the imbalance between the production and accumulation of ROS and the ability of the body to neutralize and eliminate them. In the brain, oxidative stress exhibits significant effects, due to its increased metabolical activity and limited cellular regeneration. Thus, oxidative stress is a major factor in the progressive loss of neurons structures and functions, leading to the development of severe neurodegenerative disorders. In this context, recent years have witnessed tremendous advancements in the field of antioxidant therapies, with a special emphasis for neuroprotection. The aim of this paper is to provide an overview of the oxidative stress and antioxidant defense mechanisms and to present the most recent studies on antioxidant therapies for neuroprotection.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 10/28/2023 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/31614572
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