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Extensive Extranodal Involvement in a case of Non-Hodgkin's Lymphoma with sparing of lymph nodes and lymphatic organs

Authors
  • Singh, Vijay
  • Kumar, Akshay
  • Singh, Prakash
  • Ora, Manish
  • Gambhir, Sanjay
Type
Published Article
Journal
Asia Oceania Journal of Nuclear Medicine and Biology
Publisher
Mashhad University of Medical Sciences
Publication Date
Jan 01, 2021
Volume
9
Issue
1
Pages
39–44
Identifiers
DOI: 10.22038/AOJNMB.2020.47774.1324
PMID: 33392348
PMCID: PMC7701225
Source
PubMed Central
Keywords
Disciplines
  • Case Report
License
Unknown

Abstract

Non-Hodgkin lymphoma (NHL) is a group of malignant lymphoproliferative disorders arising predominantly in the lymph nodes with various clinical and histological characteristics. At least 25% of NHL originates from tissues other than lymph nodes and sometimes even from sites that do not contain lymphoid tissue. These are referred to as primary extranodal lymphomas (pENLs). pENL is a universal diagnostic challenge to the clinicians and pathologists due to their varied clinical presentations, morphological mimicry, and molecular alterations. The GIT is the most common site of pENL followed by nasopharynx/oropharynx, testis, uterus/ovary, thyroid, and central nervous system. Long bones (tibia), maxillary sinus, skin, and paraspinal soft tissues are the other rare anatomic sites of pENL. We reported a case of a 60-year-old female presented with pain and mass in the pelvis region. 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and fused PET/CT was done, which revealed extensive extranodal involvement of the lung, bilateral kidneys, uterus, ovaries, bones, and muscles with no involvement of lymph nodes or lymphomatous organs. Extensive extranodal involvement with sparing of lymphomatous organ has not been reported earlier.

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