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Extensions to pedigree analysis I. Likehood calculations for simple and complex pedigrees.

Authors
  • Lange, K
  • Elston, R C
Type
Published Article
Journal
Human heredity
Publication Date
Jan 01, 1975
Volume
25
Issue
2
Pages
95–105
Identifiers
PMID: 1150306
Source
Medline
License
Unknown

Abstract

A graph theoretic definition of pedigrees is given and a distinction drawn between simple and complex pedigrees. Algorithms are presented to calculate the likeihood of any kind of pedigree, assuming only segregation at a finite set of loci, nonassortative mating and no environmental correlations; multiple births and consanguineous marriages are explicity allowed for. The formulation given can lead to more powerful genetic counselling, segregation analysis and linkage analysis.

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