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Extension of life-span with superoxide dismutase/catalase mimetics.

Authors
  • Melov, S1
  • Ravenscroft, J
  • Malik, S
  • Gill, M S
  • Walker, D W
  • Clayton, P E
  • Wallace, D C
  • Malfroy, B
  • Doctrow, S R
  • Lithgow, G J
  • 1 Buck Institute for Age Research, Novato, CA 94949, USA.
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Sep 01, 2000
Volume
289
Issue
5484
Pages
1567–1569
Identifiers
PMID: 10968795
Source
Medline
License
Unknown

Abstract

We tested the theory that reactive oxygen species cause aging. We augmented the natural antioxidant systems of Caenorhabditis elegans with small synthetic superoxide dismutase/catalase mimetics. Treatment of wild-type worms increased their mean life-span by a mean of 44 percent, and treatment of prematurely aging worms resulted in normalization of their life-span (a 67 percent increase). It appears that oxidative stress is a major determinant of life-span and that it can be counteracted by pharmacological intervention.

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