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Extended Repertoire of Genes Encoding Variable Surface Lipoproteins in Mycoplasma bovis Strains

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Molecular Pathogenesis
Disciplines
  • Biology

Abstract

A genomic cluster of vsp genes was previously shown to mediate high-frequency phenotypic switching of surface lipoprotein antigens in the bovine pathogen Mycoplasma bovis. This study revealed that field strains of M. bovis possess modified versions of the vsp gene complex in which extensive sequence variations occur primarily in the reiterated coding sequences of the vsp structural genes. These findings demonstrate that there is a vastly expanded potential for antigenic variation within populations of this organism.

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