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Extended analyses of the Wnt/beta-catenin pathway: robustness and oscillatory behaviour.

Authors
Type
Published Article
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
581
Issue
21
Pages
4043–4048
Identifiers
PMID: 17678900
Source
Medline
License
Unknown

Abstract

The Wnt/beta-catenin signalling pathway is evolutionarily conserved across many species and plays important roles during embryogenesis. The Lee-Heinrich model (to recognize the contributions of R. Heinrich we will refer to the work proposed by Lee et al. [Lee, E., Salic, A., Krüger, R., Heinrich, R., Kirschner, M.W. (2003) The roles of APC and axin derived from experimental and theoretical analysis of the Wnt pathway. PloS Biol. 1, 116-132] as the Lee-Heinrich model) describes this pathway by use of coupled ordinary differential equations. Here, we extend this model by introducing negative feedback loops of the pathway using time-delay differential equations. Single- and multiple-parameter perturbations suggest a very robust behaviour of this pathway that can also demonstrate oscillatory behaviour. These findings are of biological significance as Wnt pathway components show oscillations during vertebrate somitogenesis.

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