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Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis.

Authors
  • Machida, Hiroyuki
  • Ito, Shuichi
  • Hirose, Tomonori
  • Takeshita, Fumihiko
  • Oshiro, Hisashi
  • Nakamura, Tomoko
  • Mori, Masaaki
  • Inayama, Yoshiaki
  • Yan, Kunimasa
  • Kobayashi, Naoto
  • Yokota, Shumpei
Type
Published Article
Journal
Nephrology Dialysis Transplantation
Publisher
Oxford University Press
Publication Date
Aug 01, 2010
Volume
25
Issue
8
Pages
2530–2537
Identifiers
DOI: 10.1093/ndt/gfq058
PMID: 20181802
Source
Medline
License
Unknown

Abstract

Injured podocytes in active LN express TLR9. This expression could be associated with proteinuria and increased anti-dsDNA antibody. This is the first report indicating that TLR9 is involved in the aetiology of LN and that it may play some role in podocyte injury.

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