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Expression of synaptotagmin and syntaxin associated with N-type calcium channels in small cell lung cancer.

Authors
  • David, P
  • el Far, O
  • Martin-Mouto, N
  • Poupon, M F
  • Takahashi, M
  • Seagar, M J
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jul 12, 1993
Volume
326
Issue
1-3
Pages
135–139
Identifiers
PMID: 8391990
Source
Medline
License
Unknown

Abstract

The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (omega-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.

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