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The expression of substance P and calcitonin gene-related peptide is associated with the severity of tendon degeneration in lateral epicondylitis

Authors
  • Han, Soo-Hong1
  • Kim, Hyung Kyung2
  • Jang, Yoon1
  • Lee, Hyeon Hae1
  • Rhie, Jeongbae3
  • Han, Donghun1
  • Oh, Jongbeom1
  • Lee, Soonchul1
  • 1 CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Gyeonggi-do, Seongnam-si, 13488, Republic of Korea , Seongnam-si (South Korea)
  • 2 Kyung Hee University Hospital at Gangdong, Kyung Hee University, College of Medicine, Seoul, Republic of Korea , Seoul (South Korea)
  • 3 Department of Occupational and Environmental Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea , Cheonan (South Korea)
Type
Published Article
Journal
BMC Musculoskeletal Disorders
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 21, 2021
Volume
22
Issue
1
Identifiers
DOI: 10.1186/s12891-021-04067-1
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundIn this study, we investigated whether substance P (SP) or calcitonin gene-related peptide (CGRP) expression is associated with tendon degeneration in patients with lateral epicondylitis.MethodsTwenty-nine patients who underwent surgical treatment for lateral epicondylitis were enrolled in the final analyses. Extensor carpi radialis brevis tendon origins were harvested for histological analysis.ResultsSP and CGRP immunostaining were negative in healthy tendons but positive in degenerative tendons; moreover, their immunoreactivity increased with degeneration severity. Univariate analysis indicated that variables such as the preoperative visual analog scale (VAS) score or SP or CGRP expression levels were significantly associated with the Movin score. However, multivariate analysis revealed that only higher SP and/or CGRP signals were associated with higher Movin scores. Elevations in SP or CGRP expression were also linked with significantly severe preoperative VAS scores.ConclusionWe demonstrated that tendon degeneration severity is associated with increased SP and CGRP expression in the biopsy samples of lateral epicondylitis.

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