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Expression of senescence-associated beta-galactosidase in enlarged prostates from men with benign prostatic hyperplasia.

Authors
Type
Published Article
Journal
Urology
0090-4295
Publisher
Elsevier
Publication Date
Volume
56
Issue
1
Pages
160–166
Identifiers
PMID: 10869659
Source
Medline
License
Unknown

Abstract

Cultured prostatic epithelial cells expressed SA-beta-gal on reaching replicative senescence in vitro. The survey of human BPH specimens for the senescent marker showed that prostatic epithelial cells in patients with BPH with more advanced enlargement of the prostate (greater than 55 g prostate weight) expressed SA-beta-gal, and the prostates from patients with BPH that weighed less than 55 g tended to lack senescent epithelial cells. On the basis of these results, we propose that the accumulation of senescent epithelial cells may play a role in the development of the prostatic enlargement associated with BPH.

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