Affordable Access

Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis.

Authors
  • Bossard, Céline
  • Souazé, Frédérique
  • Jarry, Anne
  • Bezieau, Stéphane
  • Mosnier, Jean-François
  • Patricia Forgez
  • Laboisse, Christian L
Type
Published Article
Journal
JAMA Dermatology
Publisher
American Medical Association
Publication Date
October 2007
Volume
28
Issue
10
Pages
2030–2035
Identifiers
PMID: 17870207
Source
USPC - SET - SVS
License
Unknown

Abstract

We investigated the expression of the neurotensin high-affinity receptor 1 (NTS1) during inflammatory bowel disease (IBD)-related colorectal oncogenesis, in colonic samples from 30 patients with IBD-related adenocarcinomas, dysplasias, and inflammatory mucosa (IM). The percentage of NTS1-positive epithelial cells progressively increased from the inflammatory condition to adenocarcinoma and was significantly higher in adenocarcinomas than in IM (p=0.0169). In parallel, the percentage of neurotensin (NT)-positive epithelial cells increased during the IBD-related oncogenesis. Finally, as NTS1 is a ss-catenin inducible gene, we found that a number of preneoplastic lesions and adenocarcinomas co-expressed NTS1 and beta-catenin without NT expression. Therefore, this study suggests two pathways of NTS1 overexpression during IBD-related oncogenesis: one triggered by NT overexpression, and a second associated with an activation of the APC/beta-catenin pathway, these two pathways being not mutually exclusive.

Report this publication

Statistics

Seen <100 times