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Expression of multidrug resistance-related genes (mdrl, MRP, GST-pi and DNA topoisomerase II) in urothelial cancers.

Authors
  • Kim, W J
  • Kakehi, Y
  • Wu, W J
  • Fukumoto, M
  • Yoshida, O
Type
Published Article
Journal
British journal of urology
Publication Date
Sep 01, 1996
Volume
78
Issue
3
Pages
361–368
Identifiers
PMID: 8881943
Source
Medline
License
Unknown

Abstract

These results suggest that the activation of MRP and GST-pi expression occurs during the tumorigenesis of urothelial cancers and that it may confer de novo and acquired drug resistance on urothelial cancers. These results should provide further insight into the complex role postulated for MDR-related genes in chemotherapy, carcinogenesis and tumour progression.

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