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Expression of matrix metalloproteinases in articular cartilage of temporomandibular and knee joints of mice during growth, maturation, and aging.

Authors
  • Gepstein, Amira
  • Shapiro, Sarah
  • Arbel, Gil
  • Lahat, Nitza
  • Livne, Erella
Type
Published Article
Journal
Arthritis and rheumatism
Publication Date
Dec 01, 2002
Volume
46
Issue
12
Pages
3240–3250
Identifiers
PMID: 12483728
Source
Medline
License
Unknown

Abstract

This study demonstrated changes in the protein and mRNA expression of MMPs 2, 9, 3, and 13 during growth, maturation, and aging in mice. The temporal changes were characteristic of the joint, and distinct differences were observed between the TMJ and knee cartilage. The differences in temporospatial expression of MMPs between the knee joint and TMJ may be the result of differences in load and function of these joints. The information provided in this study contributes to a better understanding of the role of these MMPs in the maintenance and integrity of cartilage tissue.

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