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Expression of MAGE gene family in lung cancers.

Authors
  • Sakata, M
Type
Published Article
Journal
The Kurume medical journal
Publication Date
Jan 01, 1996
Volume
43
Issue
1
Pages
55–61
Identifiers
PMID: 8709560
Source
Medline
License
Unknown

Abstract

MAGE gene family encodes tumor-specific antigens recognized on HLA-A1 by cytotoxic T lymphocytes. We have investigated the mRNA expression of MAGE gene family in lung cancers using MAGE gene specific primers, reverse transcription-polymerase chain reaction (RT-PCR) and restriction enzyme analysis. MAGE-1, -3, -4, -41 or -6 gene was respectively expressed in 6, 5, 6, 7, and 4 of 53 lung cancer tissues (8 to 13%) or in 0, 6, 6, 7 or 8 of 14 lung cancer cell lines (0 to 53%). These results suggest that a substantial proportion of lung cancers express MAGE genes.

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