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[The expression of hypoxia inducible factor-1,2 alpha in sporadic clear cell renal cell carcinoma and their relationships to the mutations of von Hippel-Lindau gene].

Authors
  • Gong, Kan
  • Zhang, Ning
  • Na, Xi
  • Wu, Guan
  • Yang, Xin-yu
  • Xin, Dian-qi
  • Na, Yan-qun
Type
Published Article
Journal
Zhonghua wai ke za zhi [Chinese journal of surgery]
Publication Date
Mar 15, 2005
Volume
43
Issue
6
Pages
390–393
Identifiers
PMID: 15854350
Source
Medline
License
Unknown

Abstract

Our study suggests that VHL gene mutations are frequent in sporadic CCRCC, and the high expression of HIF-1alpha and 2alpha are found in the group of VHL mutations. However, we have not found significant correlation between the expression of HIF-1alpha and 2alpha and pathological grade and stage of CCRCC in our study.

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