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Expression of human hepatic lipase in the rabbit model preferentially enhances the clearance of triglyceride-enriched versus native high-density lipoprotein apolipoprotein A-I.

Authors
Type
Published Article
Journal
Circulation
1524-4539
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Volume
107
Issue
24
Pages
3066–3072
Identifiers
PMID: 12796142
Source
Medline
License
Unknown

Abstract

These studies have shown that TG enrichment of HDL in the presence but not in the absence of in vivo expression of moderate levels of lipolytically active HL results in enhanced HDL clearance, demonstrating the important interaction between TG enrichment and HL action in the pathogenesis of HDL lowering in hypertriglyceridemic states.

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