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[Expression of hormonal receptors (alpha-estrogen, beta-estrogen, progesteron), Ki-67 and P53 in endometrium of tamoxifen treated breast cancer patients].

Authors
  • Negoiţă, M
  • Mihailovici, Maria Sultana
Type
Published Article
Journal
Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
Publication Date
Jan 01, 2011
Volume
115
Issue
3
Pages
834–838
Identifiers
PMID: 22046795
Source
Medline
License
Unknown

Abstract

The 20 endometrium specimen showed histological proliferative endometrial lessions, including polyps, hyperplasia and carcinoma. Immunohistochemical, benign lessions showned expression of estrogen alpha and beta receptor, low expression Ki-67 and absent expression of P53. These tests were negative in clear cell carcinoma, but were intens positive for Ki-67 and P53. In general, tamoxifen associated endometrial adenocarcinoma were characterized by a lower expression of estrogen receptor alpha, higher expression of progesterone receptor, and more frequent expression of estrogen receptor beta than endometrial spontaneous tumors.

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