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THE EXPRESSION OF HISTOCOMPATIBILITY ANTIGENS ON CELLULAR AND SUBCELLULAR MEMBRANES.

Authors
  • HERBERMAN, R
  • STETSON, C A Jr
Type
Published Article
Journal
The Journal of experimental medicine
Publication Date
Apr 01, 1965
Volume
121
Pages
533–549
Identifiers
PMID: 14276775
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The mouse isoantigens determined at the major histocompatibility locus known as H-2 have been found to be closely associated with the cellular surface membranes, with the membranes of the endoplasmic reticulum, and probably with those of the lysosomes as well. Mitochondrial membranes, on the other hand, show little or no H-2 antigen activity. Membrane material prepared from certain tissues, including brain and muscle, have no detectable H-2 antigenic activity. Evidence is presented which indicates that all of the H-2 antigens of the genome are expressed as a unit, supporting the hypothesis that the complex H-2 genetic locus consists of a single cistron. It is postulated that these histocompatibility antigens form some structural or functional unit in the membranes of cells.

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